BY CAR

From the North of Europe you can enter trough these alpine passes:

Spluga Pass 1908 mtr. (from Zurigo, Coira, Thusis, Spluga Pass, Chiavenna, Morbegno, Sondrio, Tirano, Bormio)

Bernina Pass 2330 mtr. (from Zurigo, Coira, Tiefencastel, Julier Pass, St. Moritz, Bernina Pass, Poschiavo, Tirano, Bormio)

Stelvio Pass 2759 mtr. (from Munchen, Innsbruck, Brennero Pass, Merano, Stelvio Pass, Bormio)

BY TRAIN

From Milan trains directed to Tirano every two hours with Trenitalia. 
From the North with The Retica Railway (CH) from Coira, Zernez, St. Moritz, Bernina Pass, Tirano (tempo route time St. Moritz-Tirano 2 hours and an half)

BY AIRPLANE

Nearest Airport: Milan Malpensa, Milan Linate, Brescia, Bergamo